RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. PURPOSE: Phase II trial to study the effectiveness of paclitaxel in treating patients who have refractory or recurrent endometrial cancer.
OBJECTIVES: * Determine the therapeutic activity of paclitaxel in patients with refractory or recurrent endometrial papillary carcinoma. * Determine the objective response and duration of response in patients treated with this regimen. * Determine the acute side effects of this regimen in these patients. OUTLINE: This is a multicenter study. Patients receive paclitaxel IV over 3 hours on day 1. Treatment repeats every 3 weeks in the absence of disease progression or unacceptable toxicity. Patients are followed every 12 weeks. PROJECTED ACCRUAL: Approximately 16-29 patients will be accrued for this study.
Study Type
INTERVENTIONAL
Purpose
TREATMENT
Masking
NONE
Allgemeines Krankenhaus der Stadt Wien
Vienna, Austria
Universitair Ziekenhuis Antwerpen
Edegem, Belgium
U.Z. Gasthuisberg
Leuven, Belgium
Ospedale Mauriziano Umberto I
Torino, Italy
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Ospedale Civile
Voghera (PV), Italy
Hospitais da Universidade de Coimbra (HUC)
Coimbra, Portugal
Hospital Universitasrio San Carlos
Madrid, Spain
Queen Elizabeth Hospital
Gateshead, England, United Kingdom