SU6668 in Treating Patients With Advanced Solid Tumors

Inclusion Criteria: * Histologically confirmed advanced solid tumor for which no standard therapy exists * At least 1 measurable tumor lesion (at least 2 cm) not previously irradiated * No history of brain metastases * Negative brain CT/MRI required for patients with signs and symptoms suspicious for brain metastases * Performance status - ECOG 0-1 * WBC greater than 3,000/mm\^3 * Absolute neutrophil count greater than 1,500/mm\^3 * Platelet count greater than 100,000/mm\^3 * Hemoglobin greater than 10 g/dL * No history of bleeding diathesis * Bilirubin no greater than 1.5 times upper limit of normal (ULN) * ALT less than 2.5 times ULN * Creatinine less than 1.5 mg/dL * Creatinine clearance greater than 60 mL/min * No concurrent uncontrolled medical or psychiatric disorders * No severe iodine allergy * Not pregnant or nursing * Negative pregnancy test * Fertile patients must use effective contraception * At least 30 days since prior over-the-counter, anticancer biologic agents (e.g., shark cartilage) * No concurrent over-the-counter, anticancer biologic agents (e.g., shark cartilage) * At least 3 weeks since prior cytotoxic or cytostatic agents (6 weeks for nitrosoureas or mitomycin) * Patients with ECOG performance status 0: * Any number of prior chemotherapy regimens allowed * Patients with ECOG performance status 1: * No more than 3 prior chemotherapy regimens for metastatic or recurrent disease * The same drug given on a different schedule does not count as a different regimen * Prior adjuvant chemotherapy for non-metastatic disease or as part of a concurrent chemoradiotherapy protocol is allowed but does not count as part of the 3-regimen limit * See Disease Characteristics * See Chemotherapy * At least 3 weeks since prior radiotherapy to nonindicator lesions * No concurrent radiotherapy * At least 24 hours since prior minor surgery (e.g., central venous catheter placement) * At least 4 weeks since prior major surgery (e.g., laparotomy, thoracotomy, or craniotomy) * At least 30 days since prior anticancer herbal remedies * At least 30 days since prior investigational agents * No concurrent anticancer herbal remedies * No other concurrent investigational or anticancer medication