RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Combining more than one drug may kill more tumor cells. PURPOSE: Phase I trial to study the effectiveness of combining 3-AP with cisplatin in treating patients who have advanced cancer.
OBJECTIVES: * Determine the maximum tolerated dose of cisplatin when administered with 3-AP in patients with advanced cancer. * Determine the toxic effects of this regimen in these patients. * Determine the antitumor responses in patients treated with this regimen. OUTLINE: This is a dose-escalation study of cisplatin. Patients receive 3-AP IV over 2 hours on days 1-4 and cisplatin IV over 1 hour on days 2 and 3. Treatment repeats every 3 weeks in the absence of disease progression or unacceptable toxicity. Cohorts of 3-6 patients receive escalating doses of cisplatin until the maximum tolerated dose (MTD) is determined. The MTD is defined as the dose preceding that at which 2 of 6 patients experience dose-limiting toxicity. PROJECTED ACCRUAL: A total of 15-25 patients will be accrued for this study.
Study Type
INTERVENTIONAL
Purpose
TREATMENT
Arizona Clinical Research Center
Tucson, Arizona, United States
Yale Comprehensive Cancer Center
New Haven, Connecticut, United States
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