RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. PURPOSE: Phase II trial to study the effectiveness of DHA-paclitaxel in treating patients who have metastatic pancreatic cancer.
OBJECTIVES: * Determine the tumor response rate, duration of response, and time to disease progression in patients with metastatic carcinoma of the pancreas treated with DHA-paclitaxel. * Determine the overall survival of patients treated with this drug. * Determine the toxicity profile of this drug in these patients. * Assess the quality of life of patients treated with this drug. OUTLINE: This is a multicenter study. Patients receive DHA-paclitaxel IV over 2 hours on day 1. Treatment repeats every 21 days in the absence of disease progression or unacceptable toxicity. Quality of life is assessed at baseline, every 2 courses, and at completion of treatment. Patients are followed every 3 months. PROJECTED ACCRUAL: A total of 21-50 patients will be accrued for this study.
Study Type
INTERVENTIONAL
Purpose
TREATMENT
Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
Baltimore, Maryland, United States
NYU School of Medicine's Kaplan Comprehensive Cancer Center
New York, New York, United States
Kimmel Cancer Center of Thomas Jefferson University - Philadelphia
Philadelphia, Pennsylvania, United States
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Virginia Mason Medical Center
Seattle, Washington, United States
Kliniken Essen - Mitte
Essen, Germany
Krankenhaus Nordwest
Frankfurt, Germany
Erasmus Medical Center
Rotterdam, Netherlands
New Cross Hospital
Wolverhampton, England, United Kingdom
Beatson Oncology Centre
Glasgow, Scotland, United Kingdom