RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. PURPOSE: Phase II trial to study the effectiveness of DHA-paclitaxel in treating patients who have metastatic prostate cancer that has not responded to hormone therapy.
OBJECTIVES: * Determine the objective tumor response rate or prostate-specific antigen response, duration of response, and time to disease progression in patients with metastatic hormone-refractory prostate cancer treated with DHA-paclitaxel. * Determine the overall survival of patients treated with this drug. * Determine the toxicity profile of this drug in these patients. * Assess the quality of life of patients treated with this drug. OUTLINE: This is a multicenter study. Patients receive DHA-paclitaxel IV over 2 hours on day 1. Treatment repeats every 21 days in the absence of disease progression or unacceptable toxicity. Quality of life is assessed at baseline, every 2 courses, and off study. Patients are followed every 3 months. PROJECTED ACCRUAL: A total of 18-50 patients will be accrued for this study.
Study Type
INTERVENTIONAL
Purpose
TREATMENT
Arizona Oncology Associates
Tucson, Arizona, United States
Alta Bates Comprehensive Cancer Center
Berkeley, California, United States
Lucille Parker Markey Cancer Center, University of Kentucky
Lexington, Kentucky, United States
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.
Louisiana State University Health Sciences Center - Shreveport
Shreveport, Louisiana, United States
Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
Baltimore, Maryland, United States
Veterans Affairs Medical Center - East Orange
East Orange, New Jersey, United States
Herbert Irving Comprehensive Cancer Center
New York, New York, United States
Kimmel Cancer Center of Thomas Jefferson University - Philadelphia
Philadelphia, Pennsylvania, United States