RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Peripheral stem cell transplantation may be able to replace immune cells that were destroyed by chemotherapy used to kill tumor cells. PURPOSE: Phase II trial to study the effectiveness of chemotherapy followed by donor peripheral stem cell transplantation in treating patients who have metastatic or unresectable kidney cancer.
OBJECTIVES: * Determine the overall response rate and overall and disease-free survival of patients with unresectable or metastatic renal cell cancer treated with fludarabine and cyclophosphamide followed by allogeneic peripheral blood stem cell transplantation. * Determine the toxicity and treatment-related mortality of this regimen in these patients. * Determine the percentage of donor chimerism in patients treated with this regimen.
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
TREATMENT
Masking
NONE
Enrollment
36
CCOP - Mayo Clinic Scottsdale Oncology Program
Scottsdale, Arizona, United States
Indiana University Cancer Center
Indianapolis, Indiana, United States
Beth Israel Deaconess Medical Center
Boston, Massachusetts, United States
Mayo Clinic Cancer Center
Rochester, Minnesota, United States
Overall response rate
Time frame: Up to 5 years
Overall survival
Time frame: Up to 5 years
Disease-free survival
Time frame: Up to 5 years
Treatment-related mortality
Time frame: Up to 5 years
Percentage of donor chimerism in patients treated
Time frame: Up to 5 years
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