Treatment With Zoledronic Acid in Patients With Breast Cancer, Multiple Myeloma, and Prostate Cancer With Cancer Related Bone Lesions

Inclusion Criteria * Signed informed consent * Greater than 18 years of age * Proof of breast cancer, multiple myeloma or prostate cancer * Diagnosis of at least one cancer-related bone lesion * If patient is of child-bearing potential, negative pregnancy test and on a medically recognized form of contraception * ECOG performance status of 0,1 or 2 * Ability to read, understand and write English or Spanish language * Normal renal function * Corrected serum calcium equal to or greater than 8mg/dl Exclusion Criteria * clinically symptomatic brain metastases * hypersensitivity to Zometa or other bisphosphonates * pregnant or lactating