Assessment of Potential Interactions Between Cocaine and Tolcapone - 1

National Institute on Drug Abuse (NIDA)16 enrolled

Overview

The purpose of this study is to assess the potential interactions between intravenous (IV) cocaine and tolcapone.

Double-blind, inpatient study by screening responses to cocaine infusions of 20 and 40 mg i.v. subjects into 1 of 2 treatment groups to assess potential interactions between i.v. cocaine infusion and treatment with tolcapone.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

DOUBLE

Enrollment

Conditions

Cocaine-Related Disorders

Interventions

TolcaponeDRUG

Eligibility

Sex: ALLMin age: 18 YearsMax age: 45 Years

Medical Language ↔ Plain English

Inclusion Criteria: Volunteers dependent on cocaine and are non-treatment seeking; between 18-45 yrs of age; DSM-4 criteria for cocaine abuse or dependence Exclusion Criteria: Additional criteria available during screening at the site

Locations (1)

UCLA Integrated Substance Abuse Program

Los Angeles, California, United States

Outcomes

Primary Outcomes

Safety

Data from ClinicalTrials.gov

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