A Multicenter Phase 2 Study of CI-1040 in Patients With Advanced Nonsmall-Cell Lung, Breast, Colon and Pancreatic Cancer

Inclusion Criteria: * Patients who are at least 18 years or older who have pathological or hiostological confirmation of colorectal, nonsmall cell lung cancer, breast, or pancreas cancer. * No more than 1 prior chemo for lung or colon cancer, no more than 2 for breast no prior chemotherapy for pancreas cancer. * Original or recent tumor tissue must be available. * Patients must have been off prior chemoptherapy for 4 weeks and radiation for 3 weeks. * Patients must have adequate renal, liver, and bone marrow function, not have serious infection or life-threatening illness (unrelated to tumor). * Must be able to swallow capsules and not have gastrointestinal disorders that may affect absorption of the drug. Exclusion Criteria: * Unstable medical condition * prior chemotherapy within 4 week of screening * series infection * other tumor types * ECOG performance status of 3 or 4.