A trial in which patients over 18 years of age who are hospitalized with community acquired pneumonia and are otherwise eligible for entry into the study are randomly selected to receive one of two treatment regimens. After written informed consent is obtained, patients will receive one of the following two treatment regimens: 1) intravenous administration of azithromycin and ceftriaxone followed by azithromycin tablets, or 2) intravenous administration of levofloxacin followed by levofloxacin tablets. At least four study visits are normally conducted up to approximately one month after starting therapy. The objective of this study is to compare the safety and efficacy of the two treatment regimens.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
219
500 mg once daily
1 gram once daily for 2 to 5 days
2 x 250 mg once daily
500 mg once daily
500 mg once daily
Pfizer Investigational Site
Birmingham, Alabama, United States
Pfizer Investigational Site
Long Beach, California, United States
Pfizer Investigational Site
Sylmar, California, United States
Pfizer Investigational Site
Sarasota, Florida, United States
Pfizer Investigational Site
Columbus, Georgia, United States
Efficacy of sequential therapy with IV Zithromax® plus IV Rocephin® followed by oral Zithromax® to IV Levaquin® (levofloxacin) followed by oral Levaquin® in the treatment of moderate to severely ill subjects with community-acquired pneumonia.
Time frame: Duration of trial
Safety and toleration of IV Zithromax® plus IV Rocephin® followed by oral Zithromax® to IV Levaquin® followed by oral Levaquin®, and to compare the bacteriological response rates in subjects with a baseline pathogen.
Time frame: Duration of trial
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.
Pfizer Investigational Site
Columbus, Georgia, United States
Pfizer Investigational Site
Fort Eisenhower, Georgia, United States
Pfizer Investigational Site
Shawnee Mission, Kansas, United States
Pfizer Investigational Site
Louisville, Kentucky, United States
Pfizer Investigational Site
Detroit, Michigan, United States
...and 27 more locations