St. John's Wort Vs. Placebo in Obsessive-Compulsive Disorder.

Inclusion criteria * Female patients: at least 2 years post-menopausal, surgically sterile, or practicing a medically acceptable method of contraception. * Meets DSM-IV criteria for obsessive compulsive disorder Exclusion criteria * Primary diagnosis of major depression, dysthymia, panic disorder, social phobia, schizophrenia, schizo-affective disorder, bipolar disorder, or PTSD * Substance abuse or dependence in the past 6 months * Vascular dementia or primary degenerative dementia of the Alzheimer's type * Treatment with MAOIs, TCAs, SSRIs, venlafaxine, nefazodone, remeron, citalopram, or bupropion within 14 days of first visit. * Fluoxetine within 5 weeks of first visit. * Failure to respond to at least two adequate antidepressant trials for obsessive compulsive disorder * Investigational drugs within 30 days of baseline * Known allergy or hypersensitivity to St. John's Wort * Currently in behavior therapy for obsessive compulsive disorder ALL INQUIRIES WILL UNDERGO A PHONE SCREENING TO DETERMINE WHETHER THEY MEET ELIGIBLITY REQUIREMENTS.