Anti-CD20 in Systemic Lupus Erythematosus

Inclusion Criteria People may be eligible for this study if they: * Are 18 to 70 years of age * Agree to use a reliable method of birth control during treatment and for 6 months after treatment ends * Have SLE (by the American College of Rheumatology criteria) * Have had SLE for at least 6 months prior to screening * Have active SLE disease at the screening visit * Have organ disease (lung, stomach, intestinal, blood, kidney, and/or heart) * Have failed standard therapy, including at least 1 immunosuppressive agent, or have experienced side effects from an immunosuppressive agent that required discontinuation of treatment * Meet blood, liver, and kidney laboratory values set by the protocol * Have not taken an immunosuppressive agent for 2 weeks prior to the first treatment * Have been on a stable dose of oral corticosteroids, if taking them, for 4 weeks before the first week's visit. Oral corticosteroids may be altered as medically necessary after enrollment. * Have at least 1 elevated autoantibody level at screening visit. Exclusion Criteria People will not be eligible for this study if they: * Are pregnant or breast-feeding * Have heart, lung, nervous system, kidney, liver, stomach, intestinal, or other diseases that may place the patient at risk if participating in the trial * Have cranial neuropathy (a condition affecting the head region) * Are on blood-thinning agents to prevent blood clotting * Have a serious skin disease * Have a certain class of heart disease * Have had cancer, unless surgically cured basal cell carcinoma or cervical dysplasia * Have a long term serious infectious disease such as tuberculosis or a fungal infection that is now active, or active within 2 years of the baseline visit * Have had HIV infection or another immunosuppressive state (chemotherapy or radiation therapy) * Have received any experimental drug within 30 days of baseline visit * Have received any monoclonal antibody or similar medication within 3 months of the baseline visit * Received any intravenous, joint, or muscle injection of corticosteroids within 4 weeks of the baseline visit * Abuse alcohol or drugs * Are unwilling or unable to follow the protocol * Have poor veins for receiving injections.