Antibiotic Treatment for Infections of Short Term In-dwelling Vascular Catheters Due to Gram Positive Bacteria

Pfizer739 enrolled

Overview

This study will treat patients who have a short term central catheter that is thought to be infected with a specific bacteria (gram positive bacteria)

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

NONE

Enrollment

739

Conditions

Bacterial Infections Gram-Positive Bacterial Infections Bacteremia

Interventions

LinezolidDRUG

VancomycinDRUG

OxacillinDRUG

DicloxacillinDRUG

Eligibility

Sex: ALLMin age: 13 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Patients with a central indwelling catheter with signs and symptoms of infection Exclusion Criteria: * Patients with tunneled catheter which cannot be removed. * Patients with evidence of endovascular infection including endocarditis. * Patients with infection of permanent intravascular devices. * Patients who have received more than 1 day of another antibiotic before enrollment. * Patients with HIV and low CD4 count.

Outcomes

Primary Outcomes

The empiric treatment of patients with complicated skin and skin structure infections (cSSSI) related to an indwelling catheter;

The empiric treatment of patients with gram-positive catheter-related bloodstream infections.

Secondary Outcomes

Clinical efficacy of linezolid compared to vancomycin/oxacillin/dicloxacillin.2.Incidence of late metastatic sequelae associated with S. aureus infections in patients treated with linezolid

Data from ClinicalTrials.gov

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