Bone Marrow Transplant From Donor Using Less Toxic Conditioning for Patient With High Risk Hemoglobinopathies

Inclusion: * Patients with a haploidentical related HLA donor and hemoglobin SS, hemoglobin SC, or hemoglobin Sb0/+ thalassemia and at least one of the following conditions: 1. previous central nervous system vaso-occlusive episode with or without residual neurologic findings; 2. frequent painful vaso-occlusive episodes which significantly interfere with normal life activities and which necessitate chronic transfusion therapy; 3. recurrent SCD chest syndrome events, which necessitate chronic transfusion therapy; 4. severe anemia, which prevents acceptable quality of life and necessitates chronic transfusion therapy. * Patients with a haploidentical related HLA donor and homozygous b0/+ thalassemia or severe variants of b0/+ thalassemia and require chronic transfusion therapy. * Women of childbearing potential must have a negative pregnancy test. * Between the ages of birth and 65 years. Exclusion: * HLA identical or 5/6 HLA matched sibling donor * Biopsy proven chronic active hepatitis or portal fibrosis. * SCD chronic lung disease \> stage 3 Severe renal dysfunction defined as creatinine clearance \<40 ml/min/1.73 M2. * Severe cardiac dysfunction defined as shortening fraction \<25%. * HIV infection. * Unspecified chronic toxicity serious enough to detrimentally affect the patient's capacity to tolerate Stem Cell Transplant. * Patient or guardian(s) unable to understand the nature and risks inherent in the stem cell transplant process. * Pregnant or lactating females and those unwilling to use acceptable contraception.