Trial With HuMax-CD4 in Participants With Rheumatoid Arthritis (RA) Failing Treatment With Methotrexate (MTX) and a TNF-alpha Blocker

Inclusion Criteria: * A diagnosis of rheumatoid arthritis according to the American College of Rheumatology 1987 revised criteria (ACR) of at least 6 months duration. * Active disease at the time of screening. * Failure to tolerate MTX, or lack of efficacy after a minimum of 6 months treatment with MTX. Exclusion Criteria: * Active autoimmune disease requiring therapy (other than rheumatoid arthritis and secondary Sjögren's disease). * Syndromes such as Fibromyalgia which require chronic pain treatment. * Most past or current cancers. * Chronic or current infectious disease such as, but not limited to, chronic renal infection, chronic chest, nasal or throat infections, tuberculosis, hepatitis B and C. * History of infected joint prosthesis within 5 years. * Most active medical conditions such as heart disease, kidney disease, liver disease, blood diseases, hormonal disturbances, lung disease, psychiatric disease. * Drug or alcohol abuse. * Pregnant or breast-feeding women may not participate. Women of childbearing potential must use either contraceptive pills or an intra-uterine device for the entire study period. Note: Other protocol defined Inclusion and Exclusion criteria may apply.