Dose Escalation, Double-Blind Treatment With Duloxetine Hydrochloride Once Daily Dosing for Evaluation of Safety in Major Depression

Inclusion Criteria: * You must be at least 18 years old. * You must be diagnosed with major depressive disorder * You must be able to visit the doctor's office once a week to once every 2 weeks for a total of 8 weeks. Exclusion Criteria: * You are a woman and are pregnant or breastfeeding. * You have a current or previous major psychiatric disorder other than depression, such as bipolar disorder, schizophrenia, or other psychotic disorder. * You have a history of alcohol or drug dependence or abuse within the past 6 months. * You are allergic to the study drug or you have experienced allergic reactions when taking several medications at once. * You have a serious medical illness.