Health Effects of Early-Life Exposure to Urban Pollutants in Minority Children

National Institute of Environmental Health Sciences (NIEHS)727 enrolled

Overview

A molecular epidemiologic study of African American and Hispanic mothers and newborns to investigate the role of common urban pollutants on procarcinogenic and developmental damage.

The major objective of the proposed research is to study the impact of early-life exposures to common urban pollutants on neurobehavioral development and asthma in a sample of children living in three low-income, minority communities of New York City (Central Harlem, Washington Heights and the South Bronx). Using a molecular epidemiologic approach with monitoring, biomarkers, and clinical assessments at serial time points, we will extend our study of African-American and Latina urban mothers and children in order to follow the cohort through child age 11 years to assess the longer-term impact of exposures on child health and developmental outcomes.

Study Type

OBSERVATIONAL

Enrollment

727

Conditions

Asthma Development

Eligibility

Sex: FEMALEMin age: 18 YearsMax age: 35 YearsHealthy volunteers:

Medical Language ↔ Plain English

Enrollment eligibility was restricted to nonsmoking pregnant women 18-35 years of age who self-identified as either African American or Dominican and who had resided in northern Manhattan or the South Bronx in New York City for at least 1 year before pregnancy. Women were excluded if they used illicit drugs, had diabetes, hypertension, or known HIV, or had their first prenatal visit after the 20th week of pregnancy.

Locations (1)

Columbia University, 722 W 168th St, 12th Floor

New York, New York, United States

Outcomes

Primary Outcomes

Neurobehavioral development

Time frame: 1 to 12 years

Asthma

Time frame: 2-12 years

Data from ClinicalTrials.gov

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