Bupropion as a Smoking Cessation Aid in Alcoholics

Inclusion Criteria: * Currently a patient in the Omaha VA Medical Center, Substance Abuse Treatment Center (SATC) or at Catholic Charities Campus for Hope. * Have a diagnosis of alcohol abuse or alcohol dependence. * Smoke 20 or more cigarettes/day (may also smoke pipes/cigars). * Be interested in quitting smoking. * Provide name, addresses, and phone numbers of at least two individuals who can provide information on their alcohol, nicotine, and other drug use during the follow-up period. * If female, patient must a) be of non-childbearing potential, b) have a negative pregnancy test, c) sign a document stating they do not plan on becoming pregnant during the study. * Agree to sign informed consent. * Able to read and understand study-related forms and procedures. Exclusion Criteria: * Advanced cardiac, pulmonary, renal, or liver disease. * History of seizures. * History of brain tumor or significant head trauma. * History of bulimia or anorexia nervosa. * Current major depressive disorder or past history of panic disorders, schizophrenia, or bipolar affective disorder. * Using psychoactive drugs. * Receiving treatment with medications that lower seizure thresholds. * Use of an investigational drug in any study in the past four weeks. * Currently using any asthma medication. * Used time-released bupropion in the past 12 months. * Currently using any other treatments to stop smoking.