Multicenter AIDS Cohort Study (MACS)

National Institute of Allergy and Infectious Diseases (NIAID)7,087 enrolled

Overview

This is a comprehensive observational study of HIV infection in homosexual and bisexual men.

The Multicenter AIDS Cohort Study (MACS) provides important information about the changing nature of HIV-mediated disease progression, the impact of antiretroviral treatment, the nature of HIV pathogenesis, and viral and host genetic factors. This study will also assess the long-term patterns of therapy use and risk-taking behaviors. Patients will have study visits every 6 months. The visits will include interviews, specimen collection, and a physical examination.

Study Type

OBSERVATIONAL

Enrollment

7,087

Conditions

HIV Infections

Eligibility

Sex: MALEMin age: 18 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * HIV negative, or * HIV positive and no history or current use of highly active antiretroviral therapy (HAART), or * HIV positive HAART recipient with documentation of HAART initiation, no AIDS diagnosis prior to HAART initiation, and a CD4 cell count and HIV-1 RNA measurement within 6 months prior to first HAART use. * Sexual intercourse with men or at least 5 male or female partners in the 5 years prior to enrollment. Exclusion Criteria: * Injection drug use within 1 year of enrollment. * Perinatally acquired HIV infection.

Locations (4)

Public Health Center

Los Angeles, California, United States

CORE Health Center

Chicago, Illinois, United States

Johns Hopkins School of Public Health

Baltimore, Maryland, United States

University of Pittsburgh School of Public Health

Pittsburgh, Pennsylvania, United States

Data from ClinicalTrials.gov

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