Marijuana for HIV-Related Peripheral Neuropathy

Center for Medicinal Cannabis Research50 enrolled

Overview

To evaluate whether smoked marijuana reduces pain in people with HIV-related peripheral neuropathy.

The study will include subjects with peripheral neuropathy caused either by HIV-disease or antiretroviral medication for the treatment of HIV. A neurologist will conduct a neurological and pain evaluation to determine eligibility for the study. Subjects who meet all eligibility criteria will be admitted to the General Clinical Research Center at San Francisco General Hospital for seven days. Subjects will be randomized (like a toss of a coin) to smoke marijuana or a placebo (cigarettes with no THC).

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

DOUBLE

Enrollment

Conditions

Peripheral Nervous System Diseases HIV Infections

Interventions

Smoked MarijuanaDRUG

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

INCLUSION CRITERIA: * HIV positive. * Be 18 years or older. * Diagnosis of HIV-related painful neuropathy. * Stable antiretroviral therapy or no antiretroviral therapy for at least 8 weeks. * Prior use of marijuana, at least 6 occasions in their lifetime prior to enrollment. EXCLUSION CRITERIA: (Not allowed) * Current use of smoked tobacco products. * Current methadone treatment. * Use of smoked marijuana within 30 days of enrollment. * Diagnosis of diabetes mellitus. * Currently receiving treatment with corticosteroids. * Use of INH, dapsone or metronidazole within 8 weeks prior to enrollment. * Severe heart disease, uncontrolled high blood pressure or lung disease. * Women who are pregnant or breastfeeding.

Locations (1)

University of California, San Francisco Community Consortium

San Francisco, California, United States

Outcomes

Primary Outcomes

Change in level of HIV-related neuropathic pain as recorded on a 100mm Visual Analog Scale.

Secondary Outcomes

Change in level of experimentally-induced pain.

Data from ClinicalTrials.gov

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