Blood Collection for Research Related to Certain Diseases Involving Blood Vessels

N/AEnrolling By InvitationNCT00047996

National Heart, Lung, and Blood Institute (NHLBI)2,000 enrolled

Overview

The collection of human specimens from both patients and healthy volunteers is necessary for the development of laboratory assays to further basic and clinical research studies. This protocol defines the purposes for which specimens will be collected and establishes general conditions under which sample collection will be performed.

Study Type

OBSERVATIONAL

Enrollment

2,000

Conditions

Sickle Cell Disease

Eligibility

Sex: ALLMin age: 18 YearsMax age: 100 YearsHealthy volunteers:

Medical Language ↔ Plain English

* INCLUSION CRITERIA: Males or females of age 18 years and older can be included in the study. EXCLUSION CRITERIA: Individuals without sickle cell disease or other chronic anemias who wish to donate blood will be excluded if the hemoglobin is less than 10 g/dL for women or less than 12g/dL for men. Individuals with sickle cell disease or other chronic anemias will be excluded from donating blood samples if the hemoglobin is less than 6 g/dL. A participant s most recent CBC result, obtained in the past 12 months, will be used to determine eligibility. There are no exclusion criteria for participants donating urine.

Locations (2)

National Institutes of Health Clinical Center

Bethesda, Maryland, United States

INOVA Fairfax Hosptial

Fairfax, Virginia, United States

Outcomes

Primary Outcomes

evaluating the role of nitric oxide, inflammatory mediators, and endothelial function in inflammatory diseases of the vasculature such as sickle cell disease, coronary artery disease, pulmonary vascular or advanced lung disease, malaria, and sep...

Data from ClinicalTrials.gov

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