Alicaforsen (ISIS 2302) in Patients With Active Crohn's Disease

Inclusion Criteria 1. Age \>/= 12 years 2. Weight \>/= 36 kg 3. CDAI score of 220 - 400 4. Documentation of Crohn's disease activity by endoscopy, biopsy or imaging in the last 2 years 5. No TNF-α inhibitor treatment for three months prior to first study drug infusion Exclusion Criteria 1. Known severe, fixed, symptomatic stenosis of the small or large intestine with significant dilation 2. Extensive external fistulization (\> 3 external fistulae which are expressible with gentle compression); colostomy or ileostomy 3. Active infection, including infectious colitis, or infection with HIV, Hepatitis B or Hepatitis C 4. Malignancy within 3 years or poorly controlled medical illness 5. Requires intravenous heparin therapy or with a history of a bleeding problem