Evaluation of the Safety of and Immune Response to an HIV Vaccine in Healthy Adults

Inclusion Criteria * HIV negative. * Acceptable methods of contraception. Exclusion Criteria * Identifiable risk behavior for HIV infection, including: sexual partners of HIV positive people, sexual intercourse with a partner of unknown HIV status if that partner is reported to be at higher risk for HIV infection, gay men reporting any unprotected anal intercourse with partners of unknown status in the 12 months preceding study entry, individuals diagnosed with a sexually transmissible infection (STI) in the 12 months preceding entry that may have been acquired through anal or vaginal intercourse, individuals reporting sharing of injecting equipment in the last 12 months. * HIV candidate vaccines in a previous HIV vaccine trial. * Live attenuated vaccines within 60 days prior to entering the study. Whole killed, toxoid, or sub-unit vaccines (e.g., influenza, pneumococcal, tetanus, and hepatitis B) are not exclusionary within 4 weeks prior to the scheduled experimental HIV vaccines. * Hypersensitivity to egg products or a known history of anaphylaxis or any other serious adverse reactions to vaccination. * History of serious allergic reaction requiring hospitalization or emergency medical care (e.g., Stevens-Johnson syndrome, bronchospasm, or hypotension) to any substance. * Significant illness requiring immunomodulatory or cytotoxic therapy. * History of cancer unless there is evidence of surgical excision followed by a sufficient observation period to give a reasonable assurance of cure. * Blood products or immunoglobulins within 6 months prior to entering the study. * Experimental or investigational agents within 30 days prior to entering the study. * Recreational and/or therapeutic drug use that might compromise the study participant's safety. * Medical or psychiatric condition or occupational responsibilities that preclude compliance with the protocol. * Pregnant or lactating women.