A Study to Examine the Use of Zemplar to Increase Serum Calcium Levels in ICU Subjects

Abbott45 enrolled

Overview

A study to determine the effect of Zemplar on the regulation of serum calcium levels and the need for administration of elemental calcium in hypocalcemic intensive care patients

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

DOUBLE

Enrollment

Conditions

Hypocalcemia

Interventions

paricalcitol injection (Zemplar)DRUG

Effects on calcium regulationBEHAVIORAL

Administration of elemental Ca during hypocalcemic ICU pts.BEHAVIORAL

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * ICU patients APACHE III score between 70 - 150 at screening and within 24 hours of enrollment and a whole blood ionized calcium level less than 0.90 mmol/L or corrected whole blood calcium level less than or equal to 7.5 mg/dL. Exclusion Criteria: * Serum creatinine greater than 2.5 mg/dL

Locations (9)

Merced Heart Association

Merced, California, United States

Denver Health Medical Center

Denver, Colorado, United States

Outcomes Research Institute

Hudson, Florida, United States

Florida Hospital

Outcomes

Primary Outcomes

The primary efficacy variable will be the change from Day 1 to last day of dosing in pH adjusted, serum ionized calcium levels.

Data from ClinicalTrials.gov

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