Study of the Safety and Efficacy of SU-011,248 in Adult Patients With Advanced Kidney Cancer

Inclusion Criteria: * Eligible patients must be at least 18 years of age with a diagnosis of metastatic kidney cancer. * The patient's kidney cancer must have gotten worse during/after previous cytokine-based therapy was given. * Any side effects from prior therapy must have subsided, and blood and urine tests must show adequate bone marrow, liver, and kidney function Exclusion Criteria: * Prior treatment with any systemic therapy other than 1 prior cytokine-based treatment regimen; * Prior surgical resection of or irradiation to the only site of measurable disease; * Ongoing severe hematuria; * Other active second malignancy; * Cardiovascular diseases or conditions within the last 12 months; * Known brain metastases; * Known HIV-positive or AIDS-related illness; * Pregnant or breast-feeding women; * Current participation in other clinical trials; * Other severe acute or chronic medical conditions.