Daptomycin for the Treatment of Infections Due to Gram-Positive Bacteria

Main Inclusion Criteria: * Infection caused by Staphylococcus aureus, Staphylococcus epidermidis, Enterococcus faecalis, or Enterococcus faecium that requires inpatient hospitalization and treatment with injectable antibiotics\*\* * Site of infection: complicated skin and skin structure infection; urinary tract infection; intra-abdominal infection; infective endocarditis; or bloodstream infection (including catheter-related). * Pathogen resistant to, or patient intolerant of: beta-lactams, vancomycin, quinupristin/dalfopristin, or linezolid. * Unable to receive any other standard commercially available antibacterial therapy for the infection. Main Exclusion Criteria: * Creatinine clearance less than 40 mL/min\*\* * Hemodialysis or peritoneal dialysis * Admitted to the hospital for drug overdose or other conditions associated with rhabdomyolysis, or is expected to require repeated intramuscular injections * Creatine phosphokinase (CPK) level greater than 2.5 times above the upper limit of normal (ULN) at screening; if the elevation in CPK can be attributed to an obvious cause (eg, surgery)\*\* * Central nervous system infection * Pulmonary infection. (\*\*) An exemption may be granted for patients not satisfying these criteria following a conversation with the Medical Monitor.