Bupropion in the Treatment of Pathological Gambling

Inclusion Criteria: * Meet the criteria for Pathological Gambling (DSM-IV-TR), through the administration of the National Opinion Research Center DSM Screen for Gambling Problems(NODS); * Meet the criteria for Pathological Gambling (DSM-IV-TR), through the administration of the National Opinion Research Center DSM Screen for Gambling Problems(NODS); * Receive a score of 5 or more on the South Oaks Gambling Screen (SOGS); * Have PG for at least one year; * Have had at least 2 or more gambling episodes during the 2-week screening period; * Speak standard English; * Be able to give written informed consent. Exclusion Criteria: * Evidence of current (past 3 months) substance misuse; * Had a Hamilton Depression Rating Scale (HDRS)27 score of 18 or more (or a score on item 1 of greater than 2; * Had a current eating disorder (except binge eating disorder); * Had any history of seizures, or suicidal or aggressive behavior; * Had a urine drug screen positive for stimulants, opiates, hallucinogens, or phencyclidine; * Had a current or past psychotic disorder, bipolar disorder, or significant cognitive disorder; * Received monoamine oxidase inhibitors within 3 weeks of randomization, long acting phenothiazine within 3 months of randomization,fluoxetine within 4 weeks of randomization, or other psychotropic drugs within 2 weeks of randomization; * Had prior exposure to bupropion; * Were engaged in individual, group, or couples psychotherapy during the 2 weeks before randomization, (except Gamblers Anonymous).