Genetic Study of Familial Factors in Patients With Colon Cancer

Alliance for Clinical Trials in Oncology600 enrolled

Overview

RATIONALE: Genetic studies may help in understanding the genetic processes involved in the development of some types of cancer. PURPOSE: Clinical trial to study the cancer-related genes in patients who have colon cancer or adenomatous polyps.

OBJECTIVES: * Identify human colon neoplasia susceptibility genes in patients with colon cancer or adenomatous polyps. * Correlate the inheritance of novel susceptibility alleles for adenomatous polyposis of the colon with colon neoplasia in these patients. * Correlate colon neoplasia susceptibility with the presence of COX-2, sPLA2, and DNMT genes in these patients. * Identify a novel gene that governs increased susceptibility to colon adenoma and cancer in the genome of these patients.

Study Type

OBSERVATIONAL

Enrollment

600

Conditions

Colorectal Cancer

Interventions

cytogenetic analysisGENETIC

gene mappingGENETIC

microarray analysisGENETIC

Eligibility

Sex: ALLMax age: 70 Years

Medical Language ↔ Plain English

DISEASE CHARACTERISTICS: * Diagnosis of colon cancer or polyps at age 70 or under * Has a living full sibling with diagnosis of colon cancer or polyps at age 70 or under * No history of familial adenomatous polyposis syndrome * No hereditary nonpolyposis colon cancer, according to Amsterdam criteria * No known I1370K adenomatous polyposis of the colon susceptibility variant * Enrolled on 1 of the following clinical trials: * CLB-9581 * CLB-89803 * CLB-80001 NOTE: Patients do not need to be receiving protocol therapy. Patients who are outside the treatment protocol's follow-up range are eligible. Patients who discontinued therapy for any reason, including toxic effects, are eligible. PATIENT CHARACTERISTICS: Age * 70 and under at diagnosis Other * No significant psychiatric illness that would preclude giving informed consent * No inflammatory bowel disease (in patient or sibling)

Locations (1)

Wayne Memorial Hospital, Incorporated

Goldsboro, North Carolina, United States

Data from ClinicalTrials.gov

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