Combination Pharmacotherapy for Smoking Cessation Among Methadone Patients

Inclusion Criteria: * Patients in long-term methadone maintenance treatment * Patient smokes at least 10 cigarettes per day, are stable on their use of methadone (phase 2 or higher treatment), smoked for at least 1 year, be willing to participate for 6 months, and not have used bupropion or nicotine replacement therapy for 6 months Exclusion Criteria: * Patients who use prescription drug regimens that might affect methadone or bupropion metabolism * Patients with cardiovascular disease, asthma, COPD * Patients who are pregnant or breastfeeding * Patients with regular use of alcohol, other illicit drugs, or other types of tobacco (chewing or pipe for example)