The purpose of this study is to evaluate the impact of treating depression on substance dependent teens.
The primary study aim is to determine whether fluoxetine + CBT is a more effective treatment than placebo + CBT for substance outcomes, depression, and behavior problems. The current community standard of care often withholds pharmacotherapy for depression in substance abusing adolescents, since it is often assumed that their depressions may remit with SUD treatment alone. However, this is an untested hypothesis in adolescents and one that we propose to test in the current study.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
QUADRUPLE
Enrollment
126
single fixed morning dose 20 mg X 15 weeks
20mg, QD x 16 weeks
single fixed morning dose X 16 weeks
University of Colorado Denver
Aurora, Colorado, United States
1611 South Federal Blvd.
Denver, Colorado, United States
To determine whether fluoxetine + CBT is a more effective treatment than placebo + CBT for substance outcomes, depression, and behavior problems.
Time frame: 16 weeks
To determine if the treatment of depression with fluoxetine + CBT, in depressed adolescents with SUD and CD will be more effective than placebo + CBT in reducing substance use and improving conduct symptoms.
Time frame: 16 weeks
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