RATIONALE: Monoclonal antibodies such as yttrium Y 90 ibritumomab tiuxetan and rituximab can locate cancer cells and either kill them or deliver radioactive cancer-killing substances to them without harming normal cells. PURPOSE: This phase II trial is studying how well giving yttrium Y 90 ibritumomab tiuxetan together with rituximab works in treating patients with progressive non-Hodgkin's lymphoma.
OBJECTIVES: * Determine the efficacy of yttrium Y 90 ibritumomab tiuxetan and rituximab, in terms of overall response rate (complete, unconfirmed complete, and partial) and duration of response, in patients with transformed CD20+ B-cell non-Hodgkin's lymphoma. * Determine the safety of this regimen in these patients. * Determine the event-free survival and time to treatment progression in patients treated with this regimen. * Determine the immunogenicity of this regimen in these patients. OUTLINE: This is a multicenter study. Patients receive rituximab IV followed within 4 hours by indium In 111 ibritumomab tiuxetan IV (for imaging) over 10 minutes on day 1. Patients undergo 1 (or 2 if needed) imaging scan between days 2-5. In the absence of altered biodistribution, patients receive rituximab IV followed within 4 hours by yttrium Y 90 ibritumomab tiuxetan IV over 10 minutes on day 8. Patients are followed monthly for 3 months, every 3 months for 2 years, and then every 6 months for 2 years.
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
TREATMENT
Masking
NONE
Enrollment
84
Overall response rate
Time frame: Up to 4 years
Duration of response
Time frame: Up to 4 years
Complete response (CR), unconfirmed CR, and partial response
Time frame: Up to 4 years
Event-free survival
Time frame: Up to 4 years
Time to progression
Time frame: Up to 4 years
Time to next lymphoma treatment
Time frame: Up to 4 years
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Arkansas Cancer Research Center at University of Arkansas for Medical Sciences
Little Rock, Arkansas, United States
Providence Saint Joseph Medical Center - Burbank
Burbank, California, United States
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La Jolla, California, United States
Kaiser Permanente Medical Office -Vandever Medical Office
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Beebe Medical Center
Lewes, Delaware, United States
CCOP - Christiana Care Health Services
Newark, Delaware, United States
Rush-Copley Cancer Care Center
Aurora, Illinois, United States
University of Illinois Cancer Center
Chicago, Illinois, United States
University of Chicago Cancer Research Center
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Joliet Oncology-Hematology Associates, Limited - West
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