Dehydroepiandrosterone Effects on HIV-1 Replication

Inclusion criteria: * Evidence of HIV-1 infection * HIV RNA \<50 copies/mL * Stable antiretroviral treatment regimen for at least 8 weeks * Age 18 years or older * Normal pap smear and mammograph within 1 year (females) * Normal prostate-specific antigen level with in one year, age adjusted (males) Exclusion criteria: * Active opportunistic infections or malignancy other than localized cutaneous KS lesions * Concurrent or prior use within the past 8 weeks of DHA, testosterone, other anabolic steroids, corticosteroids, megestrol acetate, growth hormone, IL-2, or thalidomide * Diagnosis of AIDS Dementia Complex (stage II or higher) * Active substance abuse (e.g., alcohol or injection drugs) * Evidence of severe liver dysfunction or hepatic transaminases greater than 3x the upper normal limit * Pregnant or breast-feeding * History of endocrinologically-responsive tumors (e.g., breast, ovarian, uterine, or prostatic cancer, or malignant melanoma)