Delaying Alzheimer Disease Symptoms With Anti-Inflammatory Drugs

Inclusion Criteria: * NIMH diagnostic criteria for Age Associated Memory Impairment (AAMI) * Mini-Mental State Examination (MMSE) score between 26 and 30 (unless \< 8 years of educational achievement) * No significant cerebrovascular disease * Estrogen replacement therapy and thyroid replacement therapy (if the participant is euthyroid) are permitted if the therapies are stable for \> 1 month * Memory and verbal fluency cut-off scores that increase the probability of incipient dementia (Buschke-Fuld: 34; verbal fluency: 46 for letters, 7 for categories; Benton Visual Retention: 5) * Adequate visual and auditory acuity to allow neuropsychological testing * Normal screening laboratory tests and electrocardiogram (ECG) Exclusion Criteria: * Possible or probable Alzheimer Disease (AD) or other dementia * Neurologic or other physical illness that could produce cognitive deterioration * History of transient ischemic attacks (TIAs), carotid bruits, or lacunes on an MRI scan * History of myocardial infarction within the previous year or unstable cardiac disease * Uncontrolled hypertension (systolic BP \> 170 or diastolic BP \> 100) * History of significant liver disease, pulmonary disease, diabetes, or cancer * DSM-IV criteria for major psychiatric disorders within the previous 2 years * Past or present history of alcoholism or drug dependence * Untreated depression as determined by a Hamilton Depression Rating Scale (HAM-D) score of 12 or more * Drugs that may significantly affect psychometric test results * Centrally active beta-blockers, narcotics, clonidine, anti-Parkinsonian medications, antipsychotics, benzodiazepines, systemic corticosteroids, medications with significant cholinergic or anticholinergic effects, anti-convulsants, warfarin, vitamins other than the standard multivitamin supplement, ginkgo biloba, and any nutraceuticals. Occasional chloral hydrate use will be allowed, but discouraged, for insomnia. * Investigational drugs within the previous month or longer, depending on drug half-life * Contraindication for MRI scan (e.g., metal in body, claustrophobia)