Exploratory Study to Assess the Biological Activity of ZD6126 in Subjects With Newly Diagnosed Metastatic Renal Cell Carcinoma (Stage IV)

Inclusion Criteria: * Newly diagnosed metastatic renal cell carcinoma * Suitable for nephrectomy Exclusion Criteria: * Prior chemotherapy, biological therapy or radiation therapy for renal cell carcinoma or within the last 3 years for any other cancer * Significant cardiac event within 3 months of entry * Any history of coronary angioplasty or history of myocardial infarction