Antioxidant Functions of Lipoic Acid

National Center for Complementary and Integrative Health (NCCIH)16 enrolled

Overview

The goal of this study is to determine whether a short treatment with lipoic acid, an antioxidant used in the treatment of diabetic neuropathy, improves blood vessel reactivity and decreases oxidant stress in persons with elevated blood cholesterol.

As per Brief Summary

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

DOUBLE

Enrollment

Conditions

Hypercholesterolemia

Interventions

lipoic acidDRUG

Eligibility

Sex: ALLMin age: 50 YearsMax age: 75 Years

Medical Language ↔ Plain English

Inclusion criteria: * Lipid criteria for inclusion are a plasma LDL between 160 and 190 mg/dl (total cholesterol usually 240-285 mg/dl) * Less than 2 coronary risk factors, and already on a cholesterol-lowering diet. Exclusion criteria: * Overt or clinical atherosclerosis * Diabetes * Currently taking cholesterol-lowering medication. * Subjects with other lipid disorders * Subjects taking supplemental lipoic acid, vitamin C, or vitamin E.

Locations (1)

Vanderbilt University Medical Center

Nashville, Tennessee, United States

Data from ClinicalTrials.gov

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