Botanical/Drug Interactions in HIV: Glucuronidation

Inclusion criteria: * Absence of HIV-1 infections * Body mass index less than or equal to 30 kg/m2 and weigh at least 50 kg. * Laboratory values obtained within 7 days of study entry within normal range for healthy volunteers. * Able to be compliant with dosing schedules and diary record keeping. * Able to follow dietary restrictions associated with the protocol. * Ability and willingness to provide informed consent * All women of reproductive potential must have a negative pregnancy test * All women of reproductive potential to use contraception methods as defined by protocol * All study subjects (male and female) must agree to not participate in a conception process Exclusion Criteria: * History of any acute or chronic illness that requires current medical therapy including active gastrointestinal conditions that might interfere with drug absorption. * History of hepatic, renal, cardiovascular, gastrointestinal diseases. * Current gastrointestinal disturbance. * Receipt of any prescribed or over the counter medication or ingested CAM during the 30 days prior to study entry except: Over the counter acetaminophen or ibuprofen at doses not exceeding package labeling guidelines. * Any medical condition that, in the opinion of the investigator, would interfere with the subject's ability to participate in this protocol. * Pregnancy or breastfeeding. * Allergy/sensitivity to study agent(s) or their formulations. * Active drug or alcohol abuse or dependence, which in the opinion of the investigator would interfere with adherence to study requirements or would endanger the subject's health while on study. * Before entering the study, subjects must agree not to consume alcohol for 48 hours prior to PK sampling days. * Participation in any investigational drug studies within 30 days prior to study entry and during study.