The purpose of this study is to determine the relationship between dexamethosone (steroid) and children's sleep and fatigue.
Approximately 134 children and adolescents will be enrolled. All children and adolescents will wear a wrist actigraph for two consecutive 5-day study periods. Children and adolescents will have blood drawn 2 times on Day 1 when they are on dexamethosone. Their parents will complete a sleep diary and fatigue questionnaire by telephone on Days 2 and 5 of both study periods.
Study Type
INTERVENTIONAL
Allocation
NON_RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
134
10 day study cycle: 5 day observation pre-steroid,5 day observation post-steroid
St. Jude Children Research Hospital
Memphis, Tennessee, United States
Fatigue and sleep quality changes
Time frame: 10 days
Pharmacogenetics with dextamethasone use
Time frame: 5 days
Pharmacokinetics with dextamethasone use
Time frame: 5 days
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