DC Vaccine Combined With IL-2 and IFNα-2a in Treating Patients With mRCC

Inclusion Criteria: * Histologically confirmed metastatic renal cell carcinoma with measurable disease. * Tumor tissue available and properly stored for lysate preparation. * Patients must be at least 4 weeks from their last immunotherapy, radiation, surgery or chemotherapy (6 weeks for nitrosureas) and recovered from all ill effects. * Karnofsky Performance Status ≥60% * Life expectancy ≥ twelve weeks * Adequate end organ function: * Hematological: ANC ≥ 1000cells/μL, platelets ≥ 75,000/μL, hemoglobin ≥ 8.5 g/dl * Liver: AST \< 2 x ULN (upper limit of normal) unless due to metastases then \< 5 x ULN, serum total bilirubin \< 2 x ULN (except for patients with Gilbert's Syndrome) * Renal: serum creatinine \< 2.0 x ULN. * Pulmonary: FEV1 \> 2.0 liters or \> 75% of predicted for height and age. * Cardiac: No evidence of congestive heart failure, symptoms of coronary artery disease, myocardial infarction less than 6 months prior to entry, or serious cardiac arrhythmias. Patients over 40 or have had previous myocardial infarction greater than 6 months prior to entry will be required to have a negative or low probability cardiac stress test for cardiac ischemia. * CNS: No history of brain metastases. * Women should not be lactating and, if of childbearing age, have a negative pregnancy test within two weeks of entry to the study. * Appropriate Contraception in both sexes EXCLUSION CRITERIA: * Patients may have not have been treated previously with IL-2, IFNα or autologous vaccine. * Concomitant second malignancy except for non-melanoma skin cancer, and non- invasive cancer such as cervical CIS, superficial bladder cancer without local recurrence, breast CIS. * In patients with a prior history of invasive malignancy, less than five years in complete remission * Positive serology for HIV, hepatitis B or hepatitis C, * Significant co-morbid illness such as uncontrolled diabetes or active infection that would preclude treatment on this regimen. * Use of corticosteroids or other immunosuppression (if patient had been taking steroids, at least 4 weeks must have passed since the last dose). * History of autoimmune disease.