This study was designed to determine how effective and safe Ispinesib is in treating locally advanced or metastatic Non-small Cell Lung cancer in patients who have received a platinum-based chemotherapy and whose disease continues to progress. Treatment involves a 1-hr treatment given intravenously (IV), repeated once every 21 days. A patient may continue treatment as long as they are benefiting from the treatment. Blood samples will be taken at specific times over 24 hr period to measure the amount of drug in your body at specific times after the drug is given. Blood samples will also be taken for routine lab tests such as complete blood counts and clinical chemistries. Physical exams will be performed before each treatment.
Study Type
INTERVENTIONAL
Allocation
NON_RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
70
GSK Investigational Site
Scottsdale, Arizona, United States
GSK Investigational Site
Jacksonville, Florida, United States
GSK Investigational Site
Rochester, Minnesota, United States
GSK Investigational Site
Rochester, New York, United States
GSK Investigational Site
Greensboro, North Carolina, United States
GSK Investigational Site
Philadelphia, Pennsylvania, United States
GSK Investigational Site
Memphis, Tennessee, United States
GSK Investigational Site
Brussels, Belgium
GSK Investigational Site
Edegem, Belgium
GSK Investigational Site
Leuven, Belgium
...and 1 more locations
Assessment of Overall Response Rate of tumor.
Safety and tolerability: adverse events, changes from baseline in vital signs and clinical laboratory parameters.
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