This is a 12-week study for the treatment of chronic persistent symptoms in participants with schizophrenia. Participants on a stable, optimal dose of up to two atypical antipsychotics who fulfill the screening criteria will be randomized to receive either an FDA-approved drug or placebo in addition to the current treatment. Safety will be closely monitored through vital signs, various tests, and blood and urine samples.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
DOUBLE
Enrollment
209
Change from baseline in the total score of the Positive and Negative Symptom Scale (PANSS) at Week 12.
Time frame: 12 Weeks
- Efficacy - Change from baseline in PANSS positive symptoms at Week 12 - Change from baseline in the Scale for the Assessment of Negative Symptoms (SANS) at Week 12 - Change from baseline in PANSS general psychopathology symptoms at Week 12.
Time frame: 12 Weeks
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GSK Investigational Site
Little Rock, Arkansas, United States
GSK Investigational Site
Garden Grove, California, United States
GSK Investigational Site
Glendale, California, United States
GSK Investigational Site
Los Angeles, California, United States
GSK Investigational Site
Pico Rivera, California, United States
GSK Investigational Site
San Diego, California, United States
GSK Investigational Site
Sherman Oaks, California, United States
GSK Investigational Site
Coral Springs, Florida, United States
GSK Investigational Site
Maitland, Florida, United States
GSK Investigational Site
Miami, Florida, United States
...and 29 more locations