Safety and Effectiveness of Two Doses of ABT-874 as Compared to Placebo in Subjects With Multiple Sclerosis (MS)

Inclusion Criteria: * Age between 18 and 55 years * Diagnosis of active relapse within 12 months of screening. * At least one relapse within 12 months of screening. * Must be able to walk at least 65 feet with or without assistance * Off Copaxone or interferon therapy for two months prior to screening * Able and willing to learn to self-administer weekly injections, or have a designee who will administer study medication * Female participants must use contraceptives while on study drug Exclusion Criteria: * Primary progressive multiple sclerosis (PPMS) * Immunosuppressive therapy (such as azathioprine, methotrexate (MTX), but excluding corticosteroids) within six months of randomization. Subjects with previous treatment with cyclophosphamide, total lymphoid irradiation, mitoxantrone, cladribine, or bone marrow transplantation, regardless of duration, will be excluded from participation in this study * Systemic corticosteroid therapy within four weeks prior to the first screening Magnetic Resonance Imaging (MRI) * Participation in any clinical study, whether or not it involves an investigational drug within three months prior to the screening visit * Use of any investigational drug with disease-modifying potential for the treatment of multiple sclerosis (MS) within six months of randomization (prior use of investigational agents for the symptomatic treatment of MS, e.g., 4-aminopyridine (4-AP), may be allowed following discussion with medical monitor * Concomitant statin use in doses exceeding the manufacturers' maximum recommended daily dosages for treatment of hypercholesterolemia or as part of an MS disease-modifying protocol * Infection or risk factors for severe infections * Excessive immunosuppression or other factors associated with it, including human immunodeficiency virus (HIV) infection * Severe, recurrent, or persistent infections \[such as Hepatitis B or C, or borreliosis or recurrent urinary tract infection (UTI) (\> 3 UTIs requiring antibiotic treatment per year) or recurrent pneumonia (\> 2 pneumonias requiring antibiotic treatment per year) or infected decubitus ulcers\] * Evidence of current inactive tuberculosis (TB) infection; recent exposure to mycobacterium tuberculosis (converters to a positive purified protein derivative \[PPD\]). Subjects with a positive PPD or a chest X-ray suggestive of prior TB infection will be excluded * Active tuberculosis disease * Active chronic Lyme disease * Active syphilis * Any other significant infection requiring hospitalization or intravenous (IV) antibiotics in the month prior to Screening; or * Infection requiring treatment with antibiotics in the two weeks prior to Screening. * Any of the following risk factors for development of malignancy: * History of lymphoma or leukemia * Cutaneous squamous-cell or basal cell carcinoma (EXCEPT if treated more that two years prior to Screening with evidence of recurrence or residual disease) * Other malignancy (EXCEPT if treated more than five years prior to Screening without evidence of recurrence or residual disease) or * Disease associated with an increased risk of malignancy (such as familial polyposis). * History of major immunologic reaction (such as serum sickness or anaphylactoid reaction) to an Immunoglobulin G (IgG) containing agent (such as intravenous (IV) gamma globulin, a fusion protein, or monoclonal antibody) * Confounders of the assessment of neurologic response including other diseases that produce chronic neurologic manifestations (such as amyotrophic lateral sclerosis, Guillain-Barre syndrome, Lyme disease, myasthenia gravis, etc.) * Prior exposure to anti-IL-12 antibodies * Confounders of safety assessment, such as an unstable medical condition not related to MS (including those requiring an adjustment of treatment in the four weeks prior to Screening) * Exacerbation of asthma requiring hospitalization in the ten years prior to Screening (subjects with asthma not requiring hospitalization should be discussed with the medical monitor prior to Screening) * Pregnant or lactating females * The following exclusionary laboratory values at screening or baseline: * Hemoglobin (Hgb) \<10 g/dL in females or \<12 g/dL in males; * White blood cell (WBC) count \<3 x 109/L; * Platelet count \<100 x 109/L * Serum aspartate transaminase (AST) or alanine transaminase (ALT) x 3 upper limits of normal (ULN); * Serum total bilirubin \>/= 3 mg/dL (\>/= 51 x mol/L) * Serum creatinine \>1.6 mg/dL (\> 141 x mol/L) * Subject has a recent history of substance abuse or psychiatric illness that could preclude compliance with the protocol * In the eight weeks prior to study drug administration, the subject has received a transfusion of any blood product, or has had 500 mL or more of blood removed by repetitive or one-time blood donation, plasmapheresis, or plasma exchange, or has lost 550 mL or more blood because of hemorrhage; or * For any reason, subject is considered by the investigator to be an unsuitable candidate to receive ABT-874.