Study of LJP 394 in Lupus Patients With History of Renal Disease

Inclusion Criteria: * Diagnosis of Systemic Lupus Erythematosus (SLE) * Active SLE renal disease within past 4 years. * Males or females between 12 and 70 years old. * Females must be non-pregnant and non-lactating. Females and males must use adequate birth control methods during course of study. * Ability to have weekly intravenous (IV) administration of study treatment. Exclusion Criteria: * Active SLE renal disease within past 3 months prior to entering study. * Use of the following therapies within 3 months prior to entering the study: alkylating agents, e.g., cyclophosphamide, TNF inhibitors, cyclosporine. * Use of mycophenolate mofetil that exceeds 1000 mg/day, azathioprine that exceeds 100 mg/day, methotrexate that exceeds 10 mg/week, leflunomide that exceeds 10 mg/day within 2 months prior to entering study. * Use of rituximab within 6 months prior to entering study. * Current abuse of drugs or alcohol.