Nine Month Course of Anti-HIV Medications for People Recently Infected With HIV

Inclusion Criteria for Step 1: * Recently infected with HIV * No prior antiretroviral therapy (ART) * CD4 count of 350 cells/mm3 or more AND a CD4% of 14% or more within 21 days prior to study entry * HIV viral load of 500 copies/ml or more within 21 days prior to study entry * Required laboratory values obtained within 21 days prior to study entry * 18 years or older * Ability and willingness to provide written informed consent * Willing to use acceptable forms of contraception Exclusion Criteria for Step 1: * HIV progression to CDC category B or C disease * Pregnancy or breastfeeding * History of pancreatitis or coronary artery disease * Prior ART. Participants who took antiretrovirals for postexposure prophylaxis more than one year prior to study entry are not excluded. * Certain medications within 21 days prior to study entry. Participants who agree to receive an alternative ART regimen approved by the investigator will not be excluded. * Previously received an investigational anti-HIV vaccine * Current therapy with systemic corticosteroids. Patients who are taking a short course (less than 21 days) of corticosteroids are not excluded. * Current therapy with systemic chemotherapeutic agents; nephrotoxic systemic agents; immunomodulatory treatments, including interleukin-2; or investigational agents * Known allergy or sensitivity to study drugs or their formulations * Current alcohol or drug use that, in the opinion of the investigator, would interfere with the study * Serious medical or psychiatric illness that, in the opinion of the investigator, would interfere with the study * Hepatitis B surface antigen positive within 21 days prior to study entry * Known resistance to one or more components of the study drug regimen Inclusion Criteria for Step 2: * subjects in DT arm who meet one of the following five criteria will be advised to enter step 2 and initiate ART: 1. CD4 cell counts below 350 cells/mm3 on 2 consecutive determinations at least 4 weeks apart at or after the step 1, week 12 study visit 2. HIV-1 RNA above 750,000 copies/mL confirmed on 2 consecutive determinations at least 1 week apart at or after the step 1, week 4 study visit 3. HIV-1 RNA above 200,000 copies/mL on 2 consecutive determinations at least 1 week apart at or after the step 1, week 12 study visit 4. Clinical progression to CDC category B or C disease 5. CD4 count below 200 cells/mm3 or CD4 percent less than 14% at any time on study * subjects in IT arm who meet one of the following five criteria after discontinuing study medications will be advised to enter step 2 and re-initiate ART: 1. CD4 cell counts below 350 cells/mm3 on 2 consecutive determinations at least 4 weeks apart at or after the step 1, week 12 post-treatment- discontinuation study visit 2. HIV-1 RNA above 750,000 copies/mL confirmed on 2 consecutive determinations at least 1 week apart at or after the step 1, week 4 post-treatment- discontinuation study visit 3. HIV-1 RNA above 200,000 copies/mL on 2 consecutive determinations at least 1 week apart at or after the step 1, week 12 post-treatment- discontinuation study visit 4. Clinical progression to CDC category B or C disease 5. CD4 count below 200 cells/mm3 or CD4 percent less than 14% at any time on study Exclusion Criteria for Step 2: * Pregnancy or breastfeeding Inclusion Criteria for Step 3: * Study participants who were on Step 1, IT arm and had completed or ended prematurely the 36 week course of early ART and did not on ART either because they did not meet eligibility criteria for Step 2 or because they did not start ART even after meeting the Step 2 eligibility criteria. * Study participants on Step 1, DT arm who were not on ART either because they did not meet eligibility criteria for Step 2 or because they did not start ART even after meeting the Step 2 eligibility criteria. * Previous A5217 participants who had either completed the study or ended prematurely their participation in the study, AND were not on ART either because they never met eligibility criteria for Step 2 or because they had not started ART even after meeting the Step 2 eligibility criteria. * All A5217 participants who were on Step 1 and in the midst of their 36 weeks of randomized ART and who completed a portion or all of the 36 weeks of originally recommended therapy, AND chose then to interrupt their ART. Exclusion Criteria for Step 3: * Participants who were on Step 1, IT arm of the study receiving ART. * Participants in Step 2 or who had otherwise initiated long-term ART, regardless of whether they were on treatment.