Safety of and Immune Response to an HIV-1 Vaccine Boost (VRC-HIVADV014-00-VP) in HIV Uninfected Adults Who Participated in HVTN 052

Inclusion Criteria: * Previously enrolled in and have completed all 3 study vaccine injections for HVTN 052 * Understanding of vaccination procedure * Good general health * HIV uninfected * Hepatitis B surface antigen negative * Anti-hepatitis C virus (HCV) antibody negative, or negative for HCV PCR if the anti-HCV is positive * Willing to use acceptable forms of contraception Exclusion Criteria: * Immunosuppressive medications within 168 days prior to study * Blood products within 120 days prior to study * Immunoglobulin within 60 days prior to study * Live attenuated vaccines within 30 days prior to study * Investigational research agents within 30 days prior to study * Medically indicated subunit or killed vaccines within 14 days prior to study * Allergy shots within 30 days prior to study * Current anti-tuberculosis prophylaxis or therapy * Anaphylaxis or other serious adverse reactions to vaccines. A person who had an adverse reaction to pertussis vaccine as a child is not excluded. * Autoimmune disease or immunodeficiency * Active syphilis infection * Unstable asthma (e.g., daily symptoms; use of oral or orally inhaled corticosteroids or other treatments; emergent care, urgent care, hospitalization, or intubation during the past 2 years) * Diabetes mellitus. A participant with past gestational diabetes is not excluded. * Thyroid disease, including removal of thyroid and diagnoses requiring medication. A participant not requiring thyroid medication during the last year is not excluded. * Serious angioedema. A participant who has had an episode of angioedema over 3 years prior to the study, and has not required medications for at least 2 years, is not excluded. * Uncontrolled hypertension * Diagnosis of bleeding disorder * Malignancy, except those with a surgical excision that has a reasonable assurance of sustained cure and/or is unlikely to recur during the period of the study * Seizure disorder requiring medication within the last 3 years * Absence of the spleen * Mental illness that would interfere with compliance with the protocol * Pregnancy or breastfeeding