Effectiveness of Two Approved Drugs in Lowering High Cholesterol (0733-224)

Organon and Co571 enrolled

Overview

The purpose of this study is to evaluate the safety and effectiveness of two approved drugs in lowering high cholesterol when taken together, compared to taking only one of the drugs.

The duration of treatment is 12 weeks.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

DOUBLE

Enrollment

571

Conditions

Hypercholesterolemia

Interventions

MK0733, simvastatinDRUG

Comparator: simvastatinDRUG

Eligibility

Sex: ALLMin age: 21 YearsMax age: 65 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Elevated cholesterol level Exclusion Criteria: * Liver disease * Known allergies to study drugs

Outcomes

Primary Outcomes

Fasting triglyceride levels at 12 weeks.

Secondary Outcomes

Total Cholesterol, LDL-C, HDL-C, VLDL-C, VLDL-TG, Apo A-I, and Apo B, CRP, PAI-1, fibrinogen, fasting plasma glucose, and fasting insulin

Data from ClinicalTrials.gov

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