Antihypertensive Efficacy and Safety of Approved Drugs in Japanese Patients With Essential Hypertension (Banyu Study)(0954A-302)

Organon and Co840 enrolled

Overview

The purpose of this study is to evaluate antihypertensive (lowering blood pressure) effectiveness of three combinations of approved study drugs compared to both study drugs being given alone.

The duration of treatment is 3.5 months.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

DOUBLE

Enrollment

840

Conditions

Hypertension

Interventions

MK0954A, hydrochlorothiazide (+) losartan potassiumDRUG

Comparator: placebo, losartan, hydrochlorothiazideDRUG

Eligibility

Sex: ALLMin age: 25 YearsMax age: 74 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Japanese ancestry * Stable high blood pressure defined by the study criteria Exclusion Criteria: * Pregnant or nursing * Significant concurrent kidney, liver, blood, or other disease * Recent heart attack or heart surgery * History of stroke, severe hypertension (high blood pressure), significant heart failure or cardiac arrhythmias * Significant lab abnormalities * Uncontrolled blood sugar * History of certain drug allergies

Outcomes

Primary Outcomes

Mean trough SiDBP after 8 weeks of treatment

Secondary Outcomes

Safety

Data from ClinicalTrials.gov

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