Development of Human Laboratory Study Model of Cocaine Relapse Prevention II - 1

National Institute on Drug Abuse (NIDA)16 enrolled

Overview

To study of classical conditioning mechanisms associated with arousal, craving and cocaine use.

This is a single-site, double-blind, placebo-controlled crossover study of classical conditioning mechanisms associated with arousal, craving and cocaine use.

Study Type

INTERVENTIONAL

Enrollment

Conditions

Cocaine-Related Disorders

Interventions

Cocaine (IV)DRUG

Eligibility

Sex: ALLMin age: 18 YearsMax age: 55 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Be English-speaking volunteers who are cocaine dependent * Be non-treatment seeking at the time of the study * Meet DSM-IV criteria for cocaine dependence * Have ECG showing normal sinus rhythm, normal conductivity, and non clinically significant arrhythmias * Females must provide a negative pregnancy test and agree to use birth control * Have baseline laboratory tests within normal limits Exclusion Criteria: * Please contact site for more information

Locations (1)

University of Texas Health Science Center

San Antonio, Texas, United States

Outcomes

Primary Outcomes

Stimulated and non-stimulated craving

Cocaine assessment

Data from ClinicalTrials.gov

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