Predictors of Cognitive Decline in Normal Aging

Inclusion Criteria: * Males and females, from all racial and ethnic categories between the ages of 60-80 years of age, with English as their first language. * Residents of the New York City metropolitan area. * Minimum of 12 years of education. * Participants will be grouped according to the following classifications: normal aging, mild cognitive impairment (MCI), Alzheimer's disease (AD), or frontotemporal dementia (FTD). * Participants will agree to ApoE genotyping and DNA banking. Exclusion Criteria: * Past history or MRI evidence of brain damage including significant trauma, stroke, hydrocephalus, lacunar infarcts, seizures, mental retardation or serious neurological disorder. * Significant history of alcoholism or drug abuse. * History of psychiatric illness (e.g., schizophrenia, mania or depression). * Any focal signs or significant neuropathology. * A score of 4 or greater on the Modified Hachinski Ischemia Scale suggesting cerebrovascular disease. * A total score of 16 or more on the Hamilton Depression Scale to exclude possible cases of primary depression. * Evidence of clinically relevant and uncontrolled hypertensive, cardiac, pulmonary, vascular, metabolic or hematologic conditions. * Physical impairment of such severity as to adversely affect the validity of psychological testing. * Hostility or refusal to cooperate. * Any prosthetic devices (e.g., pacemaker or surgical clips) that could be affected by the magnetic field employed during MRI imaging. * History of familial early onset dementia.