Study Evaluating TMI-005 in Active Rheumatoid Arthritis

Inclusion Criteria: * Meet American College of Rheumatology (ACR) criteria for RA * Have active RA * Disease duration of at least 6 months * Disease onset at \> 16 years of age. Exclusion Criteria: * Any prior use of anti-TNF alpha biologics, rituximab, receipt of anti-CD4 or diphtheria interleukin-2 fusion protein or other immunosuppressive biologics (except for anakinra) * Largely or wholly incapacitated with the subject bedridden or confined to a wheelchair, permitting limited or no self-care * Pregnant or breastfeeding women or women planning to become pregnant during the study or within 12 weeks after the last dose of test article