APC-111 Once a Day (QD) for 7 Days vs. Penicillin Taken Four Times a Day (QID) for 10 Days in Patients With Strep Throat

Inclusion Criteria: * Give informed consent, assent and patient authorization * Age 12 and over * A clinical diagnosis of acute pharyngitis or tonsillitis * A positive rapid Strep test * Can swallow the oral study dosage forms * Females must have a negative urine pregnancy test and be using acceptable birth control if sexually active Exclusion Criteria: * Chronic or recurrent odynophagia * Need for hospitalization or IV antimicrobial therapy * Pharyngitis known or suspected due to a pathogen resistant to beta-lactam antimicrobials * Known carrier of S. pyogenes * Allergies to penicillin or other beta-lactam antibiotics * Any serious illness or concomitant condition that the investigator judges will preclude inclusion to the study * Seizure disorder * Pregnant or nursing * Expectation of additional systemic antibacterials would be required for another condition * Current drug or alcohol abuse * Any experimental drug or device within the last 30 days * Prior systemic antibiotic therapy within the last 30 days * Hospitalization within the last month which included antibacterial therapy * The presence of clinically significant hematologic conditions, etc * Probenecid treatment